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translocations or amplifications along with the genomic alterations by now present in the original CLL, but lack the typical mutations observed in Main DLBCL indicating that they may correspond to a unique biological class.Deep, qualified next-generation sequencing has disclosed that subclonal mutations (i.e., those present in only a fraction of tumor cells) is usually detected for all driver genes and are related to swift condition progression and weak result.11–thirteen This is particularly relevant for TP53
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